Ontology highlight
ABSTRACT:
SUBMITTER: Lindstrom E
PROVIDER: S-EPMC5845353 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Lindström Erik E Rizoska Biljana B Tunblad Karin K Edenius Charlotte C Bendele Alison M AM Maul Don D Larson Michael M Shah Neha N Yoder Otto Valerie V Jerome Chris C Grabowska Urszula U
Journal of translational medicine 20180309 1
<h4>Background</h4>MIV-711 is a highly potent and selective cathepsin K inhibitor. The current article summarizes the therapeutic effects of MIV-711 on joint pathology in rabbits subjected to anterior cruciate ligament transection (ACLT), and the prophylactic effects on joint pathology in dogs subjected to partial medial meniscectomy, two surgical models of osteoarthritis (OA).<h4>Methods</h4>Starting 1 week after surgery, rabbits were dosed daily via oral gavage with either MIV-711 or vehicle ( ...[more]