The prognostic value of sST2 and galectin-3 considering different aetiologies in non-ischaemic heart failure.

ABSTRACT: Objective:Several studies indicate a prognostic value of sST2 and galectin-3 in heart failure (HF). While previous studies focused on ischaemic cause of HF, we investigated the role of sST2 and galectin-3 in patients with non-ischaemic dilated cardiomyopathy (DCM). Methods:sST2 and galectin-3 serum concentrations were measured in 262 subjects with DCM. Survival rates were determined for all-cause mortality (ACM) and cardiac mortality (CM). Results:In a univariate model, sST2 as a continuous variable was a predictor of ACM (HR 1.05;?95% CI 1.03 to 1.07,?P<0.001) and CM (HR 1.03;?95% CI 1.00 to 1.06, P=0.040). In the subgroup of patients with inflammatory and/or viral DCM (DCMi?viral), the endpoints ACM (HR 1.10;?95% CI 1.05 to 1.17,?P<0.001) and CM (HR 1.10;?95% CI 1.02 to 1.18, P=0.013) were significant. In the subgroup of patients with idiopathic DCM, the endpoint ACM (HR 1.04;?95% CI 1.01 to 1.07, P=0.019) was significant. In a multivariate model, the prognostic value of the sST2 main group remained intact for ACM (HR 1.04; 95%?CI 1.02 to 1.07, P=0.003).Univariate and multivariate analysis of galectin-3 as continuous variable did not show any significant result. However, in a quartile model, intermediate values of galectin-3 were significantly associated with a lower event rate of ACM and CM. Conclusion:The study revealed that sST2 predicts ACM and CM in patients with non-ischaemic HF and could be useful especially in patients with inflammatory background. Our findings that intermediate levels of galectin-3 allow for better prognosis were new and different to other investigations. Trial registration number:NCT03090425; Results.

SUBMITTER: Binas D 

PROVIDER: S-EPMC5845404 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature