Ontology highlight
ABSTRACT:
SUBMITTER: Casabona MG
PROVIDER: S-EPMC5845736 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Microbiology (Reading, England) 20171124 12
The Staphylococcus aureus type VII protein secretion system (T7SS) plays important roles in virulence and intra-species competition. Here we show that the T7SS in strain RN6390 is activated by supplementing the growth medium with haemoglobin, and its cofactor haemin (haem B). Transcript analysis and secretion assays suggest that activation by haemin occurs at a transcriptional and a post-translational level. Loss of T7 secretion activity by deletion of essC results in upregulation of genes requi ...[more]