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Atorvastatin treatment softens human red blood cells: an optical tweezers study.

ABSTRACT: Optical tweezers are proven indispensable single-cell micro-manipulation and mechanical phenotyping tools. In this study, we have used optical tweezers for measuring the viscoelastic properties of human red blood cells (RBCs). Comparison of the viscoelastic features of the healthy fresh and atorvastatin treated cells revealed that the drug softens the cells. Using a simple modeling approach, we proposed a molecular model that explains the drug-induced softening of the RBC membrane. Our results suggest that direct interactions between the drug and cytoskeletal components underlie the drug-induced softening of the cells.

SUBMITTER: Sheikh-Hasani V

PROVIDER: S-EPMC5846528 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Atorvastatin treatment softens human red blood cells: an optical tweezers study.

Sheikh-Hasani Vahid V Babaei Mehrad M Azadbakht Ali A Pazoki-Toroudi Hamidreza H Mashaghi Alireza A Moosavi-Movahedi Ali Akbar AA Reihani Seyed Nader Seyed SNS

Biomedical optics express 20180220 3

Optical tweezers are proven indispensable single-cell micro-manipulation and mechanical phenotyping tools. In this study, we have used optical tweezers for measuring the viscoelastic properties of human red blood cells (RBCs). Comparison of the viscoelastic features of the healthy fresh and atorvastatin treated cells revealed that the drug softens the cells. Using a simple modeling approach, we proposed a molecular model that explains the drug-induced softening of the RBC membrane. Our results s ...[more]

PMID: 29541518

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