Reevaluation of immune activation in the era of cART and an aging HIV-infected population.

ABSTRACT: Biological aging is associated with immune activation (IA) and declining immunity due to systemic inflammation. It is widely accepted that HIV infection causes persistent IA and premature immune senescence despite effective antiretroviral therapy and virologic suppression; however, the effects of combined HIV infection and aging are not well defined. Here, we assessed the relationship between markers of IA and inflammation during biological aging in HIV-infected and -uninfected populations. Antibody response to seasonal influenza vaccination was implemented as a measure of immune competence and relationships between IA, inflammation, and antibody responses were explored using statistical modeling appropriate for integrating high-dimensional data sets. Our results show that markers of IA, s

SUBMITTER: de Armas LR 

PROVIDER: S-EPMC5846952 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature