Ontology highlight
ABSTRACT:
SUBMITTER: Korsunsky I
PROVIDER: S-EPMC5847100 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20170717 7
MicroRNAs have been established as key regulators of tumor gene expression and as prime biomarker candidates for clinical phenotypes in epithelial ovarian cancer (EOC). We analyzed the coexpression and regulatory structure of microRNAs and their co-localized gene targets in primary tumor tissue of 20 patients with advanced EOC in order to construct a regulatory signature for clinical prognosis. We performed an integrative analysis to identify two prognostic microRNA/mRNA coexpression modules, ea ...[more]