Higher Levels of a Cytotoxic Protein, Vaginolysin, in Lactobacillus-Deficient Community State Types at the Vaginal Mucosa.
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ABSTRACT:
SUBMITTER: Nowak RG
PROVIDER: S-EPMC5847449 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Publications
Higher Levels of a Cytotoxic Protein, Vaginolysin, in Lactobacillus-Deficient Community State Types at the Vaginal Mucosa.
Nowak Rebecca G RG Randis Tara M TM Desai Purnahamsi P He Xin X Robinson Courtney K CK Rath Jessica M JM Glover Elbert D ED Ratner Adam J AJ Ravel Jacques J Brotman Rebecca M RM
Sexually transmitted diseases 20180401 4
Vaginolysin (VLY), a cytotoxic protein produced by Gardnerella vaginalis, may contribute to bacterial vaginosis. We observed that women with G. vaginalis, low levels of lactobacilli, history of vaginal douching, higher Nugent scores, and higher vaginal pH had increased VLY. Inflammatory markers were not highly expressed with increasing VLY. Vaginolysin's role in bacterial vaginosis warrants further evaluation. ...[more]
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