Ontology highlight
ABSTRACT:
SUBMITTER: Rosenberg A
PROVIDER: S-EPMC5848027 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Rosenberg Ari A Mahalingam Devalingam D
Journal of gastrointestinal oncology 20180201 1
Pancreatic adenocarcinoma (PAC) remains one of the leading causes of cancer-related death. Despite multiple advances in targeted and immune therapies, the 5-year survival in advanced PAC remains poor. In this review, we discuss some of the unique aspects of the tumor microenvironment (TME) in PAC that may contribute to its resistance to immune therapies, as well as opportunities to potentially overcome some of these inherent barriers. Furthermore, we discuss strategies to enable immune therapies ...[more]