Fully Zwitterionic Nanoparticle Antimicrobial Agents through Tuning of Core Size and Ligand Structure.
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ABSTRACT:
SUBMITTER: Huo S
PROVIDER: S-EPMC5848071 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Fully Zwitterionic Nanoparticle Antimicrobial Agents through Tuning of Core Size and Ligand Structure.
Huo Shuaidong S Jiang Ying Y Gupta Akash A Jiang Ziwen Z Landis Ryan F RF Hou Singyuk S Liang Xing-Jie XJ Rotello Vincent M VM
ACS nano 20160916 9
Zwitterionic nanoparticles are generally considered nontoxic and noninteracting. Here, we report effective and selective antimicrobial activity of zwitterionic gold nanoparticles (AuNP) through modulation NP size and surface charge orientation. Using a set of 2, 4, and 6 nm core AuNPs, increasing particle size increased antimicrobial efficiency through bacterial membrane disruption. Further improvement was observed through control of the ligand structure, generating antimicrobial particles with ...[more]
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