Characterization of the Venom of C. d. cumanesis of Colombia: Proteomic Analysis and Antivenomic Study.
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ABSTRACT:
SUBMITTER: Quintana-Castillo JC
PROVIDER: S-EPMC5848186 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
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Characterization of the Venom of C. d. cumanesis of Colombia: Proteomic Analysis and Antivenomic Study.
Quintana-Castillo Juan Carlos JC Vargas Leidy Johana LJ Segura Cesar C Estrada-Gómez Sebastian S Bueno-Sánchez Julio César JC Alarcón Juan Carlos JC
Toxins 20180217 2
The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic facies, and paralysis of the respiratory muscles, which can lead to death. Identification and analysis of C. d. cumanensis showed nine groups of proteins responsible for the neurotoxic effect, of which ...[more]
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