Dataset Information

Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project.

ABSTRACT:

Background

Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship.

Methods

One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression.

Results

Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced.

Conclusions

The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.

SUBMITTER: Dierssen-Sotos T

PROVIDER: S-EPMC5848450 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Publications

Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project.

Dierssen-Sotos Trinidad T Palazuelos-Calderón Camilo C Jiménez-Moleón José-Juan JJ Aragonés Nuria N Altzibar Jone M JM Castaño-Vinyals Gemma G Martín-Sanchez Vicente V Gómez-Acebo Inés I Guevara Marcela M Tardón Adonina A Pérez-Gómez Beatriz B Amiano Pilar P Moreno Victor V Molina Antonio J AJ Alonso-Molero Jéssica J Moreno-Iribas Conchi C Kogevinas Manolis M Pollán Marina M Llorca Javier J

BMC cancer 20180312 1

<h4>Background</h4>Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship.<h4>Methods</h4>One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the ...[more]

PMID: 29530003

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Dataset Information

Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project.

Background

Methods

Results

Conclusions

Publications

Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project.

Similar Datasets

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