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Serum proton NMR metabolomics analysis of human lung cancer following microwave ablation.

ABSTRACT: To find potential serum biomarkers of microwave ablation (MWA) for treatment of human lung cancer by 1H nuclear magnetic resonance (NMR)-based metabolomics analysis.Serum specimens collected from 43 healthy individuals, 39 patients with advanced non-small cell lung cancer (NSCLC) and 38 NSCLC patients treated with MWA, were subjected to 1H NMR-based metabolomics analysis. Partial least squares discriminant analysis was used to analyze the data.Compared with healthy controls, NSCLC patients showed significantly elevated serum levels of lactate, alanine, glutamate, proline, glycoprotein, phenylalanine, tyrosine and tryptophan, and markedly decreased serum levels of glucose, taurine, glutamine, glycine, phosphocreatine and threonine (p

SUBMITTER: Hu JM

PROVIDER: S-EPMC5848604 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Serum proton NMR metabolomics analysis of human lung cancer following microwave ablation.

Hu Jian-Ming JM Sun Huang-Tao HT

Radiation oncology (London, England) 20180312 1

<h4>Background</h4>To find potential serum biomarkers of microwave ablation (MWA) for treatment of human lung cancer by <sup>1</sup>H nuclear magnetic resonance (NMR)-based metabolomics analysis.<h4>Methods</h4>Serum specimens collected from 43 healthy individuals, 39 patients with advanced non-small cell lung cancer (NSCLC) and 38 NSCLC patients treated with MWA, were subjected to <sup>1</sup>H NMR-based metabolomics analysis. Partial least squares discriminant analysis was used to analyze the ...[more]

PMID: 29530051

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