FIND: difFerential chromatin INteractions Detection using a spatial Poisson process.
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ABSTRACT:
SUBMITTER: Djekidel MN
PROVIDER: S-EPMC5848619 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
FIND: difFerential chromatin INteractions Detection using a spatial Poisson process.
Djekidel Mohamed Nadhir MN Chen Yang Y Zhang Michael Q MQ
Genome research 20180301 3
Polymer-based simulations and experimental studies indicate the existence of a spatial dependency between the adjacent DNA fibers involved in the formation of chromatin loops. However, the existing strategies for detecting differential chromatin interactions assume that the interacting segments are spatially independent from the other segments nearby. To resolve this issue, we developed a new computational method, FIND, which considers the local spatial dependency between interacting loci. FIND ...[more]
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