Ontology highlight
ABSTRACT:
SUBMITTER: Martin-Lopez J
PROVIDER: S-EPMC5849154 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Oncotarget 20171231 16
Non-steroidal anti-inflammatory drugs (NSAIDs) exhibit anti-neoplastic (chemoprevention) activity for sporadic cancers and the hereditary cancer predisposition Lynch syndrome (LS/HNPCC). However, the mechanism of NSAID tumor suppression has remained enigmatic. Defects in the core mismatch repair (MMR) genes <i>MSH2</i> and <i>MLH1</i> are the principal drivers of LS/HNPCC. Previous work has demonstrated that the <i>villin</i>-<i>Cre<sup>+/-</sup>Msh2<sup>flox/flox</sup></i> (VpC-Msh2) mouse is a ...[more]