Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC5849161 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Xu Yan Y Gao Ya-Wen YW Yang Yu Y
Oncotarget 20171220 16
Oxidative stress could lead to dopaminergic neuronal cell death. SC79 is a novel, selective and highly-efficient Akt activator. The current study tested its effect in dopaminergic neurons with oxidative stress. In both SH-SY5Y cells and primary murine dopaminergic neurons, pre-treatment with SC79 largely inhibited hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced cell viability reduction, apoptosis and necrosis. SC79 activated Akt in the neuronal cells, which was required for its neuroprote ...[more]