Ontology highlight
ABSTRACT:
SUBMITTER: Chan H
PROVIDER: S-EPMC5849173 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Chan Hao H Huang Hsuan-Shun HS Sun Der-Shan DS Lee Chung-Jen CJ Lien Te-Sheng TS Chang Hsin-Hou HH
Oncotarget 20180130 16
Mechanisms underlying cold-induced immunosuppression remain unclear. Here we found that cold exposure leads to transient receptor potential melastatin 8 (TRPM8)-dependent, renin-angiotensin-aldosterone system (RAAS)-mediated hypertension, which subsequently induces small molecule and fluid extravasation, increases plasma Ig levels, and elicits immunosuppression. An effect is similar to the clinically-used immunosuppressive treatments of intravenous immunoglobulin (IVIg) against various inflammat ...[more]