Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer.

ABSTRACT:

Purpose

The cell cycle mediators Aurora A and B are targets of drugs currently in clinical development. As with other targeted therapies in breast cancer, response to therapy might be associated with target expression in tumors. We therefore assessed expression of Aurora A and B in breast tumors and studied associations with clinical/pathologic variables.

Experimental design

Tissue microarrays containing primary specimens from 638 patients with 15-year follow-up were employed to assess expression of Aurora A and B using our automated quantitative analysis method; we used cytokeratin to define pixels as breast cancer (tumor mask) within the array spot and measured Aurora A and B expression within the mask using Cy5-conjugated antibodies.

Results

Aurora A and B expressi

SUBMITTER: Nadler Y 

PROVIDER: S-EPMC5849429 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature