Linking inter-individual variability to endocrine disruptors: insights for epigenetic inheritance.

ABSTRACT: Endocrine disrupting chemicals (EDCs) can induce a myriad of adverse health effects. An area of active investigation is the multi- and transgenerational inheritance of EDC-induced adverse health effects referring to the transmission of phenotypes across multiple generations via the germline. The inheritance of EDC-induced adverse health effects across multiple generations can occur independent of genetics, spurring much research into the transmission of underlying epigenetic mechanisms. Epigenetic mechanisms play important roles in the development of an organism and are responsive to environmental exposures. To date, rodent studies have demonstrated that acquired epigenetic marks, particularly DNA methylation, that are inherited following parental EDC exposure can escape embryonic epigenom

SUBMITTER: Latchney SE 

PROVIDER: S-EPMC5849504 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature