Ontology highlight
ABSTRACT:
SUBMITTER: Hollingshead S
PROVIDER: S-EPMC5849709 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Hollingshead S S Jongerius I I Exley R M RM Johnson S S Lea S M SM Tang C M CM
Nature communications 20180313 1
There is an urgent need to develop vaccines against pathogenic bacteria. However, this is often hindered by antigenic diversity and difficulties encountered manufacturing membrane proteins. Here we show how to use structure-based design to develop chimeric antigens (ChAs) for subunit vaccines. ChAs are generated against serogroup B Neisseria meningitidis (MenB), the predominant cause of meningococcal disease in wealthy countries. MenB ChAs exploit factor H binding protein (fHbp) as a molecular s ...[more]