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Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma.

ABSTRACT: Transforming growth factor-beta (TGF-?) is critical in cancer cell invasion and metastasis. The effects of a treatment that targets TGF-? using the combination of interferon alpha (IFN?)-2b and 5-fluorouracil (5-FU) are unknown. Here, we show that the serum levels of TGF-?1 prior to the therapy correlate with increased maximum tumor diameter, which is significantly (p?

SUBMITTER: Okada Y

PROVIDER: S-EPMC5849890 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Regulation of transforming growth factor is involved in the efficacy of combined 5-fluorouracil and interferon alpha-2b therapy of advanced hepatocellular carcinoma.

Okada Youhei Y Wang Ting T Kasai Kazuhiro K Suzuki Kazuyuki K Takikawa Yasuhiro Y

Cell death discovery 20180312

Transforming growth factor-beta (TGF-β) is critical in cancer cell invasion and metastasis. The effects of a treatment that targets TGF-β using the combination of interferon alpha (IFNα)-2b and 5-fluorouracil (5-FU) are unknown. Here, we show that the serum levels of TGF-β1 prior to the therapy correlate with increased maximum tumor diameter, which is significantly (<i>p</i> < 0.01) decreased after the combination therapy. 5-FU increased both the expression and secretion levels of TGF-β1 in hepa ...[more]

PMID: 29560281

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| S-EPMC10373405 | biostudies-literature

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