Molecular Epidemiology of Tuberculosis in British Columbia, Canada: A 10-Year Retrospective Study.

ABSTRACT:

Background

Understanding regional molecular epidemiology allows for the development of more efficient tuberculosis prevention strategies in low-incidence settings.

Methods

We analyzed 24-locus mycobacterial interspersed repetitive-unit-variable-number tandem repeat (MIRU-VNTR) genotyping for 2290 Mycobacterium tuberculosis clinical isolates collected in the province of British Columbia (BC), Canada, in 2005-2014. Laboratory data for each isolate were linked to case-level clinical and demographic data. These data were used to describe the molecular epidemiology of tuberculosis across the province.

Results

We detected >1500 distinct genotypes across the 4 major M. tuberculosis lineages, reflecting BC's diverse population. Disease site and clustering rates varied across

SUBMITTER: Guthrie JL 

PROVIDER: S-EPMC5850024 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature