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ABSTRACT:
SUBMITTER: Stoltzfus A
PROVIDER: S-EPMC5850294 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Stoltzfus Arlin A McCandlish David M DM
Molecular biology and evolution 20170901 9
While mutational biases strongly influence neutral molecular evolution, the role of mutational biases in shaping the course of adaptation is less clear. Here we consider the frequency of transitions relative to transversions among adaptive substitutions. Because mutation rates for transitions are higher than those for transversions, if mutational biases influence the dynamics of adaptation, then transitions should be overrepresented among documented adaptive substitutions. To test this hypothesi ...[more]