Ontology highlight
ABSTRACT:
SUBMITTER: Selisko B
PROVIDER: S-EPMC5850366 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Selisko Barbara B Papageorgiou Nicolas N Ferron François F Canard Bruno B
Viruses 20180130 2
Viral RNA-dependent RNA polymerases (RdRps) play a central role not only in viral replication, but also in the genetic evolution of viral RNAs. After binding to an RNA template and selecting 5'-triphosphate ribonucleosides, viral RdRps synthesize an RNA copy according to Watson-Crick base-pairing rules. The copy process sometimes deviates from both the base-pairing rules specified by the template and the natural ribose selectivity and, thus, the process is error-prone due to the intrinsic (in)fi ...[more]