Soft Sweeps Are the Dominant Mode of Adaptation in the Human Genome.
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ABSTRACT:
SUBMITTER: Schrider DR
PROVIDER: S-EPMC5850737 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Soft Sweeps Are the Dominant Mode of Adaptation in the Human Genome.
Schrider Daniel R DR Kern Andrew D AD
Molecular biology and evolution 20170801 8
The degree to which adaptation in recent human evolution shapes genetic variation remains controversial. This is in part due to the limited evidence in humans for classic "hard selective sweeps", wherein a novel beneficial mutation rapidly sweeps through a population to fixation. However, positive selection may often proceed via "soft sweeps" acting on mutations already present within a population. Here, we examine recent positive selection across six human populations using a powerful machine l ...[more]
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