Ontology highlight
ABSTRACT:
SUBMITTER: Fraser H
PROVIDER: S-EPMC5850906 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Molecular therapy. Methods & clinical development 20180131
The concept of regulatory T cell (Treg)-based immunotherapy has enormous potential for facilitating tolerance in autoimmunity and transplantation. Clinical translation of Treg cell therapy requires production processes that satisfy the rigors of Good Manufacturing Practice (GMP) standards. In this regard, we report our findings on the implementation of a robust GMP compliant process for the <i>ex vivo</i> expansion of clinical grade Tregs, demonstrating the feasibility of this developed process ...[more]