Dataset Information

Dissonant Representations of Visual Space in Prefrontal Cortex during Eye Movements.

ABSTRACT: We used local field potentials (LFPs) and spikes to investigate representations of visual space in prefrontal cortex and the dynamics of those representations during eye movements. Spatial information contained in LFPs of the frontal eye field (FEF) was differentially distributed across frequencies, with a majority of that information being carried in alpha and high-gamma bands and minimal signal in the low-gamma band. During fixation, spatial information from alpha and high-gamma bands and spiking activity was robust across cortical layers. Receptive fields (RFs) derived from alpha and high-gamma bands were retinocentrically organized, and they were spatially correlated both with each other and with spiking RFs. However, alpha and high-gamma RFs probed before eye movements were dissociated. Whereas high-gamma and spiking RFs immediately converged toward the movement goal, alpha RFs remained largely unchanged during the initial probe response, but they converged later. These observations reveal possible mechanisms of dynamic spatial representations that underlie visual perception during eye movements.

SUBMITTER: Chen X

PROVIDER: S-EPMC5850980 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Publications

Dissonant Representations of Visual Space in Prefrontal Cortex during Eye Movements.

Chen Xiaomo X Zirnsak Marc M Moore Tirin T

Cell reports 20180201 8

We used local field potentials (LFPs) and spikes to investigate representations of visual space in prefrontal cortex and the dynamics of those representations during eye movements. Spatial information contained in LFPs of the frontal eye field (FEF) was differentially distributed across frequencies, with a majority of that information being carried in alpha and high-gamma bands and minimal signal in the low-gamma band. During fixation, spatial information from alpha and high-gamma bands and spik ...[more]

PMID: 29466732

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Project description:BackgroundGlaucoma has been shown to lead to disability in many daily tasks including visual search. This study aims to determine whether the saccadic eye movements of people with glaucoma differ from those of people with normal vision, and to investigate the association between eye movements and impaired visual search.MethodsForty patients (mean age: 67 [SD: 9] years) with a range of glaucomatous visual field (VF) defects in both eyes (mean best eye mean deviation [MD]: -5.9 (SD: 5.4) dB) and 40 age-related people with normal vision (mean age: 66 [SD: 10] years) were timed as they searched for a series of target objects in computer displayed photographs of real world scenes. Eye movements were simultaneously recorded using an eye tracker. Average number of saccades per second, average saccade amplitude and average search duration across trials were recorded. These response variables were compared with measurements of VF and contrast sensitivity.ResultsThe average rate of saccades made by the patient group was significantly smaller than the number made by controls during the visual search task (P = 0.02; mean reduction of 5.6% (95% CI: 0.1 to 10.4%). There was no difference in average saccade amplitude between the patients and the controls (P = 0.09). Average number of saccades was weakly correlated with aspects of visual function, with patients with worse contrast sensitivity (PR logCS; Spearman's rho: 0.42; P = 0.006) and more severe VF defects (best eye MD; Spearman's rho: 0.34; P = 0.037) tending to make less eye movements during the task. Average detection time in the search task was associated with the average rate of saccades in the patient group (Spearman's rho = -0.65; P < 0.001) but this was not apparent in the controls.ConclusionsThe average rate of saccades made during visual search by this group of patients was fewer than those made by people with normal vision of a similar average age. There was wide variability in saccade rate in the patients but there was an association between an increase in this measure and better performance in the search task. Assessment of eye movements in individuals with glaucoma might provide insight into the functional deficits of the disease.

Dataset Information

Dissonant Representations of Visual Space in Prefrontal Cortex during Eye Movements.

Publications

Dissonant Representations of Visual Space in Prefrontal Cortex during Eye Movements.

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