Ontology highlight
ABSTRACT:
SUBMITTER: Handa S
PROVIDER: S-EPMC5851014 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Handa Sumit S Dempsey Daniel R DR Ramamoorthy Divya D Cook Nanci N Guida Wayne C WC Spradling Tyler J TJ White Justin K JK Woodcock H Lee HL Merkler David J DJ
Biochemistry & molecular biology journal 20180129 1
The non-mevalonate dependent (NMVA) pathway for the biosynthesis of isopentenyl pyrophosphate and dimethylallyl pyrophosphate is the sole source of these terpenoids for the production of isoprenoids in the apicomplexan parasites, in many eubacteria, and in plants. The absence of this pathway in higher organisms has opened a new platform for the development of novel antibiotics and anti-malarials. The enzyme catalyzing the first step of the NMVA pathway is 1-deoxy-D-xylulose-5-phosphate synthase ...[more]