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Directed ?-C(sp3)-H Alkylation of Carboxylic Acid Derivatives through Visible Light Photoredox Catalysis.

ABSTRACT: Visible light photoredox catalysis enables direct ?- C(sp3)-H alkylation of saturated aliphatic carbonyl compounds. Electron-deficient alkenes are used as the coupling partners in this reaction. Distinguished site selectivity is controlled by the predominant 1,5-hydrogen atom transfer of an amidyl radical generated in situ.

SUBMITTER: Chen DF

PROVIDER: S-EPMC5851452 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Directed γ-C(sp3)-H Alkylation of Carboxylic Acid Derivatives through Visible Light Photoredox Catalysis.

Chen Dian-Feng DF Chu John C K JCK Rovis Tomislav T

Journal of the American Chemical Society 20171012 42

Visible light photoredox catalysis enables direct γ- C(sp3)-H alkylation of saturated aliphatic carbonyl compounds. Electron-deficient alkenes are used as the coupling partners in this reaction. Distinguished site selectivity is controlled by the predominant 1,5-hydrogen atom transfer of an amidyl radical generated in situ. ...[more]

PMID: 29022709

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