Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
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ABSTRACT:
SUBMITTER: Perry DJ
PROVIDER: S-EPMC5852207 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Publications
Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.
Perry Daniel J DJ Wasserfall Clive H CH Oram Richard A RA Williams MacKenzie D MD Posgai Amanda A Muir Andrew B AB Haller Michael J MJ Schatz Desmond A DA Wallet Mark A MA Mathews Clayton E CE Atkinson Mark A MA Brusko Todd M TM
Scientific reports 20180314 1
Prior studies identified HLA class-II and 57 additional loci as contributors to genetic susceptibility for type 1 diabetes (T1D). We hypothesized that race and/or ethnicity would be contextually important for evaluating genetic risk markers previously identified from Caucasian/European cohorts. We determined the capacity for a combined genetic risk score (GRS) to discriminate disease-risk subgroups in a racially and ethnically diverse cohort from the southeastern U.S. including 637 T1D patients, ...[more]
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