Ontology highlight
ABSTRACT:
SUBMITTER: Menendez-Castro C
PROVIDER: S-EPMC5852238 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Menendez-Castro Carlos C Nitz Dörte D Cordasic Nada N Jordan Jutta J Bäuerle Tobias T Fahlbusch Fabian B FB Rascher Wolfgang W Hilgers Karl F KF Hartner Andrea A
Scientific reports 20180314 1
Neonatal nephron loss may follow hypoxic-ischemic events or nephrotoxic medications. Its long-term effects on the kidney are still unclear. Unlike term infants, preterm neonates less than 36 weeks gestational age show ongoing nephrogenesis. We hypothesized that nephron loss during nephrogenesis leads to more severe renal sequelae than nephron loss shortly after the completion of nephrogenesis. Rats show nephrogenesis until day 10 of life resembling the situation of preterm infants. Animals were ...[more]