Ontology highlight
ABSTRACT:
SUBMITTER: Zhong Z
PROVIDER: S-EPMC5852416 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Zhong Zhen Z Grasso Laura L Sibilla Caroline C Stevens Tim J TJ Barry Nicholas N Bertolotti Anne A
The EMBO journal 20180301 6
Protein aggregation is a hallmark of diverse neurodegenerative diseases. Multiple lines of evidence have revealed that protein aggregates can penetrate inside cells and spread like prions. How such aggregates enter cells remains elusive. Through a focused siRNA screen targeting genes involved in membrane trafficking, we discovered that mutant SOD1 aggregates, like viruses, exploit cofilin-1 to remodel cortical actin and enter cells. Upstream of cofilin-1, signalling from the RHO GTPase and the R ...[more]