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Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa.

ABSTRACT: Three new compounds, tuberazines A-C (1-3), and eleven known compounds (4-14) were obtained from the ethanolic extract of Taiwanese zoanthid Palythoa tuberculosa. Compounds 1-4 are rare marine natural products with a pyrazine moiety, and compound 5 is a tricyclic tryptamine derivative isolated from nature for the first time. The structures of all isolated metabolites were determined by analyzing their IR, Mass, NMR, and UV spectrometric data. The absolute configuration of 1 was confirmed by comparing the trend of experimental electronic circular dichroism (ECD) with calculated ECD spectra. The anti-lymphangiogenic activities of new compounds were evaluated in human lymphatic endothelial cells (LECs). Of these, new compound 3 displayed the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs.

SUBMITTER: Chen SR

PROVIDER: S-EPMC5852475 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa.

Chen Shu-Rong SR Wang Shih-Wei SW Su Chien-Jung CJ Hu Hao-Chun HC Yang Yu-Liang YL Hsieh Chi-Ting CT Peng Chia-Chi CC Chang Fang-Rong FR Cheng Yuan-Bin YB

Marine drugs 20180131 2

Three new compounds, tuberazines A-C (1-3), and eleven known compounds (4-14) were obtained from the ethanolic extract of Taiwanese zoanthid Palythoa tuberculosa. Compounds 1-4 are rare marine natural products with a pyrazine moiety, and compound 5 is a tricyclic tryptamine derivative isolated from nature for the first time. The structures of all isolated metabolites were determined by analyzing their IR, Mass, NMR, and UV spectrometric dat ...[more]

PMID: 29385063

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