MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance.
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ABSTRACT:
SUBMITTER: Martin EC
PROVIDER: S-EPMC5853108 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
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MicroRNA-335-5p and -3p synergize to inhibit estrogen receptor alpha expression and promote tamoxifen resistance.
Martin Elizabeth C EC Conger Adrienne K AK Yan Thomas J TJ Hoang Van T VT Miller David F B DF Buechlein Aaron A Rusch Douglas B DB Nephew Kenneth P KP Collins-Burow Bridgette M BM Burow Matthew E ME
FEBS letters 20170112 2
microRNAs (miRNAs) are small noncoding RNA molecules involved in the regulation of gene expression and play critical roles in human malignancies. Next-generation sequencing analysis of the MCF-7 breast cancer cell line overexpressing miR-335-5p and miR-335-3p demonstrated that the miRNA duplex repressed genes involved in the ERα signaling pathway, and enhanced resistance of MCF-7 cells to the growth inhibitory effects of tamoxifen. These data suggest that despite its conventional role in tumor s ...[more]
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