Ontology highlight
ABSTRACT:
SUBMITTER: van Lieshout LP
PROVIDER: S-EPMC5853240 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
van Lieshout Laura P LP Soule Geoff G Sorensen Debra D Frost Kathy L KL He Shihua S Tierney Kevin K Safronetz David D Booth Stephanie A SA Kobinger Gary P GP Qiu Xiangguo X Wootton Sarah K SK
The Journal of infectious diseases 20180301 6
The 2013-2016 West Africa outbreak demonstrated the epidemic potential of Ebola virus and highlighted the need for counter strategies. Monoclonal antibody (mAb)-based therapies hold promise as treatment options for Ebola virus infections. However, production of clinical-grade mAbs is labor intensive, and immunity is short lived. Conversely, adeno-associated virus (AAV)-mediated mAb gene transfer provides the host with a genetic blueprint to manufacture mAbs in vivo, leading to steady release of ...[more]