Ontology highlight
ABSTRACT:
SUBMITTER: Moylan DC
PROVIDER: S-EPMC5853445 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Moylan David C DC Pati Sunil K SK Ross Shannon A SA Fowler Karen B KB Boppana Suresh B SB Sabbaj Steffanie S
The Journal of infectious diseases 20171101 9
The role of human cytomegalovirus (HCMV)-specific T-cell responses in breast milk of HCMV-seropositive mothers is not well defined. In these studies, we demonstrate that the frequency of cytomegalovirus (CMV)-pp65-specific T-cell responses in peripheral blood mononuclear cells (PBMCs) and breast milk cells (BMCs) is increased for CD8+ T cells in both sample sources when compared with CD4+ T cells. The frequency of pp55-specific CD8 T cells producing interferon γ (IFN-γ) alone or dual IFN-γ/granz ...[more]