Enteric Helminths Promote Salmonella Coinfection by Altering the Intestinal Metabolome.
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ABSTRACT:
SUBMITTER: Reynolds LA
PROVIDER: S-EPMC5853568 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Enteric Helminths Promote Salmonella Coinfection by Altering the Intestinal Metabolome.
Reynolds Lisa A LA Redpath Stephen A SA Yurist-Doutsch Sophie S Gill Navkiran N Brown Eric M EM van der Heijden Joris J Brosschot Tara P TP Han Jun J Marshall Natalie C NC Woodward Sarah E SE Valdez Yanet Y Borchers Christoph H CH Perona-Wright Georgia G Finlay B Brett BB
The Journal of infectious diseases 20170401 8
Intestinal helminth infections occur predominantly in regions where exposure to enteric bacterial pathogens is also common. Helminth infections inhibit host immunity against microbial pathogens, which has largely been attributed to the induction of regulatory or type 2 (Th2) immune responses. Here we demonstrate an additional 3-way interaction in which helminth infection alters the metabolic environment of the host intestine to enhance bacterial pathogenicity. We show that an ongoing helminth in ...[more]
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