Longitudinal evaluation of Tau-P301L transgenic mice reveals no cognitive impairments at 17 months of age.

ABSTRACT:

Introduction

Tau is a microtubule-associated binding protein implicated in neurodegenerative tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD). These diseases result in the intracellular accumulation of hyperphosphorylated tau in the form of neurofibrillary tangles, the presence of which is associated with cognitive deficits.

Methods

We conducted a longitudinal behavioral study to provide a profile of the TgTau(P301L)23027 transgenic mouse in multiple cognitive domains across multiple ages. P301L is the tau mutation most frequently observed in patients with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) and this mouse model recapitulates the progressive development of glial and neurofibrillary tangles, and associat

SUBMITTER: Kent BA 

PROVIDER: S-EPMC5853624 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature