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Transcriptome Assessment of Erythema Migrans Skin Lesions in Patients With Early Lyme Disease Reveals Predominant Interferon Signaling.


ABSTRACT: Background:The most common clinical manifestation of early Lyme disease is the erythema migrans (EM) skin lesion that develops at the tick bite site typically between 7 and 14 days after infection with Borreliella burgdorferi. The host-pathogen interactions that occur in the skin may have a critical role in determining outcome of infection. Methods:Gene arrays were used to characterize the global transcriptional alterations in skin biopsy samples of EM lesions from untreated adult patients with Lyme disease in comparison to controls. Results:The transcriptional pattern in EM biopsies consisted of 254 differentially regulated genes (180 induced and 74 repressed) characterized by the induction of chemokines, cytokines, Toll-like receptors, antimicrobial peptides, monocytoid cell activation markers, and numerous genes annotated as interferon (IFN)-inducible. The IFN-inducible genes included 3 transcripts involved in tryptophan catabolism (IDO1, KMO, KYNU) that play a pivotal role in immune evasion by certain other microbial pathogens by driving the differentiation of regulatory T cells. Conclusions:This is the first study to globally assess the human skin transcriptional response during early Lyme disease. Borreliella burgdorferi elicits a predominant IFN signature in the EM lesion, suggesting a potential mechanism for spirochetal dissemination via IDO1-mediated localized immunosuppression.

SUBMITTER: Marques A 

PROVIDER: S-EPMC5853807 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Transcriptome Assessment of Erythema Migrans Skin Lesions in Patients With Early Lyme Disease Reveals Predominant Interferon Signaling.

Marques Adriana A   Schwartz Ira I   Wormser Gary P GP   Wang Yanmei Y   Hornung Ronald L RL   Demirkale Cumhur Y CY   Munson Peter J PJ   Turk Siu-Ping SP   Williams Carla C   Lee Chyi-Chia Richard CR   Yang Jun J   Petzke Mary M MM  

The Journal of infectious diseases 20171201 1


<h4>Background</h4>The most common clinical manifestation of early Lyme disease is the erythema migrans (EM) skin lesion that develops at the tick bite site typically between 7 and 14 days after infection with Borreliella burgdorferi. The host-pathogen interactions that occur in the skin may have a critical role in determining outcome of infection.<h4>Methods</h4>Gene arrays were used to characterize the global transcriptional alterations in skin biopsy samples of EM lesions from untreated adult  ...[more]

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