Genetic Variation at IFNL4 Influences Extrahepatic Interferon-Stimulated Gene Expression in Chronic HCV Patients.
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ABSTRACT:
SUBMITTER: Rosenberg BR
PROVIDER: S-EPMC5853921 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
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Genetic Variation at IFNL4 Influences Extrahepatic Interferon-Stimulated Gene Expression in Chronic HCV Patients.
Rosenberg Brad R BR Freije Catherine A CA Imanaka Naoko N Chen Spencer T ST Eitson Jennifer L JL Caron Rachel R Uhl Skyler A SA Zeremski Marija M Talal Andrew A Jacobson Ira M IM Rice Charles M CM Schoggins John W JW
The Journal of infectious diseases 20180101 4
Polymorphisms at IFNL4 strongly influence spontaneous resolution and interferon therapeutic response in hepatitis C virus (HCV) infection. In chronic HCV, unfavorable alleles are associated with elevated interferon (IFN)-stimulated gene (ISG) expression in the liver, but extrahepatic effects are less well characterized. We used RNA sequencing (RNA-Seq) to examine whether IFNL4 genetic variation (rs368234815) modulates ISG expression in peripheral blood mononuclear cells (PBMC) during chronic HCV ...[more]
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