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Genetic association of liver X receptor beta rs2695121 polymorphism with obesity-related traits in a northeastern Iranian population.

ABSTRACT: Background:Liver X receptor Beta (LXR?), located in an obesity susceptible region, has been shown to be involved in the metabolism of lipid and carbohydrates. Previous human genetic studies have suggested genetic variability of LXR? could be associated with human obesity. Therefore, we hypothesized that LXR? gene rs2695121 polymorphism may be associated with the risk of obesity in a northeastern Iranian population. Methods:A TaqMan allelic discrimination assay was used to genotype LXR? rs2695121 polymorphism in this cross-sectional study of 168 obese, 209 overweight and 76 normal-weight subjects recruited from Mashhad city in Iran. Logistic regression analyses were used to analyze alleles and genotypes distribution. Anthropometrics and clinical variables among different genotype carriers were compared by univariate analyses. All statistical analysis was performed using SPSS v.16.0. Results:Allelic and genotypic associations with obesity were not significant for the rs2695121 variant even after adjustment for age and gender (OR=1.17, 95% CI=0.46-2.91), p=0.586). Moreover, haplotype analysis using data from the other variant (rs17373080) of LXR? revealed no significant association (p=0.88). However, among the clinical and metabolic parameters tested, systolic and diastolic blood pressures were found nominally associated with the genotype CT (p=0.031 and p=0.017 respectively). Conclusion:This study failed to demonstrate any association between the rs2695121 variant of LXR? and obesity neither alone nor when considered with rs17373080. However, its association with blood pressure may influence one's susceptibility to obesity, supporting further studies in a larger population.

SUBMITTER: Mehrad-Majd H

PROVIDER: S-EPMC5854001 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Genetic association of liver X receptor beta rs2695121 polymorphism with obesity-related traits in a northeastern Iranian population.

Mehrad-Majd Hassan H Ghayour-Mobarhan Majid M Zali Mohamad-Reza MR

Electronic physician 20180125 1

<h4>Background</h4>Liver X receptor Beta (LXRβ), located in an obesity susceptible region, has been shown to be involved in the metabolism of lipid and carbohydrates. Previous human genetic studies have suggested genetic variability of LXRβ could be associated with human obesity. Therefore, we hypothesized that LXRβ gene rs2695121 polymorphism may be associated with the risk of obesity in a northeastern Iranian population.<h4>Methods</h4>A TaqMan allelic discrimination assay was used to genotype ...[more]

PMID: 29588827

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Project description:Background and aimsObesity is a growing public health concern in Bangladesh, which is influenced by a complex interplay of genetic and environmental factors. The genetic variant rs9939609 of the FTO (fat mass and obesity-associated) gene has been found to be associated with an increased risk for obesity, depending on the population studied. The purpose of this cross-sectional study is to examine the relationship between the FTO gene polymorphism (rs9939609) and lifestyle-related risk factors, and their impact on obesity-related traits and biochemical parameters in the Bangladeshi population.MethodsA total of 280 participants were enrolled in this study, comprising of 140 individuals with overweight and obesity (body mass index [BMI] ≥ 23.0) and 140 non-overweight healthy individuals (18.5 ≤ BMI ≥ 22.9). Demographic information, dietary behaviors, and physical activity-related data were collected using a structured questionnaire. Additionally, anthropometric assessments and measurements of biochemical parameters such as lipid profile and C-reactive protein were performed. The amplification refractory mutation system-polymerase chain reaction technique was used to identify single-nucleotide polymorphism in the FTO gene. Descriptive statistics, χ,2 and one-way ANOVA were performed to evaluate the relationships between independent and dependent variables.ResultsThe presence of rs9939609 was strongly associated with the obesity risk factors of increased BMI, cholesterol, triglycerides, and low-density lipoprotein. We also found a significant association (p < 0.05) of rs9939609 with overweight and obesity in codominant AA versus TT (odds ratio [OR] = 0.299, 95% CI: 0.129-0.695) and AA versus AT (OR = 2.273, 95% CI: 1.023-5.053), recessive TT versus AA+AT (OR = 5.154, 95% CI: 2.463-10.782), and overdominant AT versus AA+TT (OR = 0.244, 95% CI: 0.122-0.488) models.ConclusionFTO variant rs9939609 is significantly linked to obesity and an increased risk of hyperlipidemia in the Bangladeshi population. However, this association is intertwined with environmental factors such as diet and physical activity.

Dataset Information

Genetic association of liver X receptor beta rs2695121 polymorphism with obesity-related traits in a northeastern Iranian population.

Publications

Genetic association of liver X receptor beta rs2695121 polymorphism with obesity-related traits in a northeastern Iranian population.

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