Ontology highlight
ABSTRACT:
SUBMITTER: Silva DAAD
PROVIDER: S-EPMC5854376 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Silva Djalma A Alves da DAAD Silva Marcos V da MVD Barros Cleyson C Oliveira CCO Alexandre Patrícia B Dias PBD Timóteo Rodolfo P RP Catarino Jonatas S JS Sales-Campos Helioswilton H Machado Juliana R JR Rodrigues Denise B R DBR Oliveira Carlo J CJ Rodrigues Virmondes V
PloS one 20180315 3
Tuberculosis (TB) is a granulomatous disease that has affected humanity for thousands of years. The production of cytokines, such as IFN-γ and TNF-α, is fundamental in the formation and maintenance of granulomas and in the control of the disease. Recently, the introduction of TNF-α-blocking monoclonal antibodies, such as Infliximab, has brought improvements in the treatment of patients with chronic inflammatory diseases, but this treatment also increases the risk of reactivation of latent tuberc ...[more]