Ontology highlight
ABSTRACT:
SUBMITTER: Kinnunen SM
PROVIDER: S-EPMC5854571 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Kinnunen Sini M SM Tölli Marja M Välimäki Mika J MJ Gao Erhe E Szabo Zoltan Z Rysä Jaana J Ferreira Mónica P A MPA Ohukainen Pauli P Serpi Raisa R Correia Alexandra A Mäkilä Ermei E Salonen Jarno J Hirvonen Jouni J Santos Hélder A HA Ruskoaho Heikki H
Scientific reports 20180315 1
Transcription factors are fundamental regulators of gene transcription, and many diseases, such as heart diseases, are associated with deregulation of transcriptional networks. In the adult heart, zinc-finger transcription factor GATA4 is a critical regulator of cardiac repair and remodelling. Previous studies also suggest that NKX2-5 plays function role as a cofactor of GATA4. We have recently reported the identification of small molecules that either inhibit or enhance the GATA4-NKX2-5 transcr ...[more]