Ontology highlight
ABSTRACT:
SUBMITTER: Gaddis DE
PROVIDER: S-EPMC5854619 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Gaddis Dalia E DE Padgett Lindsey E LE Wu Runpei R McSkimming Chantel C Romines Veronica V Taylor Angela M AM McNamara Coleen A CA Kronenberg Mitchell M Crotty Shane S Thomas Michael J MJ Sorci-Thomas Mary G MG Hedrick Catherine C CC
Nature communications 20180315 1
Regulatory T (Treg) cells contribute to the anti-inflammatory response during atherogenesis. Here we show that during atherogenesis Treg cells lose Foxp3 expression and their immunosuppressive function, leading to the conversion of a fraction of these cells into T follicular helper (Tfh) cells. We show that Tfh cells are pro-atherogenic and that their depletion reduces atherosclerosis. Mechanistically, the conversion of Treg cells to Tfh cells correlates with reduced expression of IL-2Rα and pST ...[more]