Ontology highlight
ABSTRACT:
SUBMITTER: Busquets-Garcia A
PROVIDER: S-EPMC5854793 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Busquets-Garcia Arnau A Gomis-González Maria M Salgado-Mendialdúa Victòria V Galera-López Lorena L Puighermanal Emma E Martín-García Elena E Maldonado Rafael R Ozaita Andrés A
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20170817 5
Cannabis affects cognitive performance through the activation of the endocannabinoid system, and the molecular mechanisms involved in this process are poorly understood. Using the novel object-recognition memory test in mice, we found that the main psychoactive component of cannabis, delta9-tetrahydrocannabinol (THC), alters short-term object-recognition memory specifically involving protein kinase C (PKC)-dependent signaling. Indeed, the systemic or intra-hippocampal pre-treatment with the PKC ...[more]