Ontology highlight
ABSTRACT:
SUBMITTER: Zhang MY
PROVIDER: S-EPMC5854849 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Blood 20180119 10
Effective vaccines against malaria caused by <i>Plasmodium falciparum</i> are still lacking, and the molecular mechanism of the host-parasite interaction is not fully understood. Here we demonstrate that the interaction of RAP2, a parasite-secreted rhoptry protein that functions in the parasitophorous vacuole formation stage of the invasion, and CD147 on the host erythrocyte is essential for erythrocyte invasion by <i>P falciparum</i> and is independent from all previously identified interaction ...[more]