Ontology highlight
ABSTRACT:
SUBMITTER: Sears CR
PROVIDER: S-EPMC5854959 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Sears Catherine R CR Zhou Huaxin H Justice Matthew J MJ Fisher Amanda J AJ Saliba Jacob J Lamb Isaac I Wicker Jessica J Schweitzer Kelly S KS Petrache Irina I
American journal of respiratory cell and molecular biology 20180301 3
Cigarette smoke (CS) exposure is a major risk factor for the development of emphysema, a common disease characterized by loss of cells comprising the lung parenchyma. The mechanisms of cell injury leading to emphysema are not completely understood but are thought to involve persistent cytotoxic or mutagenic DNA damage induced by CS. Using complementary cell culture and mouse models of CS exposure, we investigated the role of the DNA repair protein, xeroderma pigmentosum group C (XPC), on CS-indu ...[more]