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The role of tumor microenvironment in resistance to anti-angiogenic therapy.

ABSTRACT: Anti-angiogenic therapy has been demonstrated to increase progression-free survival in patients with many different solid cancers. Unfortunately, the benefit in overall survival is modest and the rapid emergence of drug resistance is a significant clinical problem. Over the last decade, several mechanisms have been identified to decipher the emergence of resistance. There is a multitude of changes within the tumor microenvironment (TME) in response to anti-angiogenic therapy that offers new therapeutic opportunities. In this review, we compile results from contemporary studies related to adaptive changes in the TME in the development of resistance to anti-angiogenic therapy. These include preclinical models of emerging resistance, dynamic changes in hypoxia signaling and stromal cells during treatment, and novel strategies to overcome resistance by targeting the TME.

SUBMITTER: Ma S

PROVIDER: S-EPMC5854986 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The role of tumor microenvironment in resistance to anti-angiogenic therapy.

Ma Shaolin S Pradeep Sunila S Hu Wei W Zhang Dikai D Coleman Robert R Sood Anil A

F1000Research 20180315

Anti-angiogenic therapy has been demonstrated to increase progression-free survival in patients with many different solid cancers. Unfortunately, the benefit in overall survival is modest and the rapid emergence of drug resistance is a significant clinical problem. Over the last decade, several mechanisms have been identified to decipher the emergence of resistance. There is a multitude of changes within the tumor microenvironment (TME) in response to anti-angiogenic therapy that offers new ther ...[more]

PMID: 29560266

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