Ontology highlight
ABSTRACT:
SUBMITTER: Gomez-Lamarca MJ
PROVIDER: S-EPMC5855320 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Gomez-Lamarca Maria J MJ Falo-Sanjuan Julia J Stojnic Robert R Abdul Rehman Sohaib S Muresan Leila L Jones Matthew L ML Pillidge Zoe Z Cerda-Moya Gustavo G Yuan Zhenyu Z Baloul Sarah S Valenti Phillippe P Bystricky Kerstin K Payre Francois F O'Holleran Kevin K Kovall Rhett R Bray Sarah J SJ
Developmental cell 20180222 5
A key feature of Notch signaling is that it directs immediate changes in transcription via the DNA-binding factor CSL, switching it from repression to activation. How Notch generates both a sensitive and accurate response-in the absence of any amplification step-remains to be elucidated. To address this question, we developed real-time analysis of CSL dynamics including single-molecule tracking in vivo. In Notch-OFF nuclei, a small proportion of CSL molecules transiently binds DNA, while in Notc ...[more]