Ontology highlight
ABSTRACT:
SUBMITTER: Meraviglia V
PROVIDER: S-EPMC5855641 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Meraviglia Viviana V Bocchi Leonardo L Sacchetto Roberta R Florio Maria Cristina MC Motta Benedetta M BM Corti Corrado C Weichenberger Christian X CX Savi Monia M D'Elia Yuri Y Rosato-Siri Marcelo D MD Suffredini Silvia S Piubelli Chiara C Pompilio Giulio G Pramstaller Peter P PP Domingues Francisco S FS Stilli Donatella D Rossini Alessandra A
International journal of molecular sciences 20180131 2
SERCA2a is the Ca<sup>2+</sup> ATPase playing the major contribution in cardiomyocyte (CM) calcium removal. Its activity can be regulated by both modulatory proteins and several post-translational modifications. The aim of the present work was to investigate whether the function of SERCA2 can be modulated by treating CMs with the histone deacetylase (HDAC) inhibitor suberanilohydroxamic acid (SAHA). The incubation with SAHA (2.5 µM, 90 min) of CMs isolated from rat adult hearts resulted in an in ...[more]