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When Immune Cells Turn Bad-Tumor-Associated Microglia/Macrophages in Glioma.

ABSTRACT: As a substantial part of the brain tumor microenvironment (TME), glioma-associated microglia/macrophages (GAMs) have an emerging role in tumor progression and in controlling anti-tumor immune responses. We review challenges and improvements of cell models and highlight the contribution of this highly plastic cell population to an immunosuppressive TME, besides their well-known functional role regarding glioma cell invasion and angiogenesis. Finally, we summarize first therapeutic interventions to target GAMs and their effect on the immunobiology of gliomas, focusing on their interaction with T cells.

SUBMITTER: Roesch S

PROVIDER: S-EPMC5855658 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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When Immune Cells Turn Bad-Tumor-Associated Microglia/Macrophages in Glioma.

Roesch Saskia S Rapp Carmen C Dettling Steffen S Herold-Mende Christel C

International journal of molecular sciences 20180201 2

As a substantial part of the brain tumor microenvironment (TME), glioma-associated microglia/macrophages (GAMs) have an emerging role in tumor progression and in controlling anti-tumor immune responses. We review challenges and improvements of cell models and highlight the contribution of this highly plastic cell population to an immunosuppressive TME, besides their well-known functional role regarding glioma cell invasion and angiogenesis. Finally, we summarize first therapeutic interventions t ...[more]

PMID: 29389898

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